Compressibility always varies with different solvents. The better the pump is set to the compressibility of the respective solvent the lower is the pump's pulsation. Chromeleon allows you to determine the optimum pre-compression control for the Dionex P580 pumps, using the Learn and Freeze commands.
The Learn command starts the learn mode for determining the compressibility of the respective solvent component. However, verify that the solvent type has been set to Custom. (For more information, refer to Practical Tips for Device Control Setting Automatic Pre-Compression Control.)
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